Here's the real reason Ozempic-like weight-loss drugs are so popular (2024)

Overweight and obesity rates have reached crisis levels and are risk factors for diabetes, heart disease, cancer, dementia, and other diseases.

The CDC estimates that that almost a third of Americans are now overweight and 42% of adults “have obesity,” now categorized as a disease. Childhood obesity is up—one in five kids are estimated to be affected.

This isn’t just an American crisis. The World Obesity Federation predicts that 51% of the world’s population will be overweight or obese within the next 12 years.

Causes include sedentary lifestyles, as more people work and play in front of computer screens, the food and beverage environment, eating more out of home, fewer safe places for physical activity, genetics, and taking certain medications.

GLP 1 drugs in action

Along have come new, highly popular GLP 1 weight loss drugs, including Ozempic, Wegovy, and Mounjaro. Oprah Winfrey did a TV special: Shame, Blame and the Weight Loss Revolution. After years of up and down weight, Oprah says it’s not your fault: Obesity is a disease. She’s losing weight on one of the new drugs and helping move the market. However, insurance coverage, including Medicare, will have the biggest impact on usage.

Brian Kay of Numerator, a research firm, reports that some 12% of respondents in their household panel are using one of the new GLP 1 drugs for diabetes and/or weight loss. About 75% say they are consuming smaller portion sizes and – based on Numerator’s purchase data – their grocery bills are down 6 to 9%. Alcohol and ice cream purchases have decreased while fish and yogurt are up. However, the main reason consumers report discontinuing the drug is cost – and then grocery spending returns to previous levels.

All this has major financial implications for the food and beverage industries, restaurants, food service operators, health insurance companies, and Medicare. And the total cost in health care, lost productivity, corporate insurance, and long-term care is enormous.

How we got here

In recent decades, food consumption has increased dramatically. The portion sizes for bagels, cheeseburgers, ice cream, restaurant servings of spaghetti, meatballs, and more are ever larger.

Many restaurant chains compete on volume meals, and consumers often equate volume with value. One result is considerable waste. ReFED, a research group, estimated that 70% of food wasted in restaurants is left on plates.

The journal Addiction describes “hyper-palatable foods” as a kind of food engineering in which fat, sodium, sugar, and other additives can also drive people to crave and overeat. Northeastern University’s Network Science Institute indicates that 73% of the U.S. food supply is ultra-processed.

Getting consumers to change their behavior is a tall order. Many are confused, misguided, or indifferent about eating healthier.

A Navy officer once told me about the difficulty of re-enlisting highly trained non-commissioned officers who became too heavy to meet Body Mass Index guidelines. “We make ‘em taller. You’d be surprised how many 5’10” guys are now 6’2”—at least on paper.”

A decade ago, the McKinsey Global Institute found that portion control was the most promising strategy for promoting a healthier lifestyle. In response, the Portion Balance Coalition (PBC) was formed as an alliance of major food and beverage companies, nonprofits, academics, and government to reduce obesity and improve health. It is led by the Business for Impact Center at Georgetown University.

Hank Cardello, the food and beverage expert chairing the Portion Balance Coalition, points out “stubborn roadblocks” to positive change. “Taste is everything. If consumers clamored for broccoli, it would be in every meal, snack, and beverage,” he says.

Recent research by the Coalition and the Natural Marketing Institute revealed five consumer segments:

  • The “Well Beings” (most health proactive) – 28% of consumers
  • The “Fence Sitters” (wannabe healthy) – 26%
  • The “Food Actives” (mainstream healthy) – 12 %
  • The “Magic Bullets” (lack commitment to a healthy lifestyle – 22%
  • The “Eat, Drink and Be Merry’s” (least health active) – 12%

The PBC concluded that the “Well Beings” and “Fence Sitters”—especially those with children—do respond to smaller portions. The “Magic Bullets” and “Eat Drink and Be Merry” cohorts are largely unresponsive but may be receptive to the new weight loss drugs as well as “stealth health” (making imperceptible changes to portion sizes and reductions in less healthy ingredients).

Cardello and others are dubious of trying to force behavior change: legislating healthier products; frightening consumers away from comfort foods; changing the definition of healthy; warning labels on package fronts; and taxing soft drinks.

Portion balance is the most promising strategy to tackle the obesity and food waste crises. Companies that offer more choices and reasonable portions can achieve higher margins, improve consumer appeal, and maintain taste.

More must-readcommentarypublished byFortune:

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  • ‘The Godmother of AI’ says California’s well-intendedAI bill will harm the U.S. ecosystem
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The opinions expressed in Fortune.com commentary pieces are solely the views of their authors and do not necessarily reflect the opinions and beliefs ofFortune.

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Here's the real reason Ozempic-like weight-loss drugs are so popular (2024)

FAQs

Why is Ozempic so popular now? ›

There is a positive impact of Ozempic and similar drugs

Previously, effective medical treatments for obesity were limited, with most medications offering modest weight loss. Ozempic and similar drugs now yield an average weight loss of 15 to 20 percent, significantly higher than previous options.

What is the problem with Ozempic? ›

Use of Ozempic has also led to muscle loss, with. Trunzo notes that more serious complications include pancreatitis and issues of the kidneys, gallbladder, and thyroid. “Anytime you're taking something that impacts hormonal functioning, you run the risk of also having nervous system side effects,” Trunzo says.

What are doctors saying about Ozempic for weight loss? ›

While Ozempic is not specifically labeled as a weight loss drug, studies sponsored by Novo Nordisk, the company that makes Ozempic, suggest people who take semaglutide—the active compound in Ozempic—may lose weight. In fact, the FDA approved semaglutide for weight loss in 2021 under the brand name Wegovy.

What is the new weight loss drug better than Ozempic? ›

Compared to Ozempic, Mounjaro might work even better for weight loss. One study showed that a 15 milligram-dose of this drug taken every week led people to lose more than 20% of their body weight. Ozempic can help you lose 15%-20% of your weight on average. But many people might lose closer to 10% of their body weight.

How did Kelly Clarkson lose so much weight? ›

As for her diet, Clarkson isn't doing anything extreme. “I eat a healthy mix,” she told People. “I dropped weight because I've been listening to my doctor — a couple (of) years I didn't. And 90% of the time I'm really good at it because a protein diet is good for me anyway.

What is the biggest side effect of Ozempic? ›

Ozempic and nausea

Nausea is the most common Ozempic side effect. Still, not everyone has it. About 1 in 5 people in the clinical trial had it. Nausea is usually mild to moderate and at its worst when you first start the drug or when you increase your dose.

What is the dark side of Ozempic? ›

Serious Side Effects

Symptoms include severe abdominal pain, nausea, and vomiting, and require immediate medical attention. Gallbladder Disease: Ozempic may increase the risk of gallbladder disease, including gallstones. Symptoms can include severe abdominal pain, fever, and jaundice.

What organ does Ozempic affect? ›

Ozempic—also known as semaglutide—has side effects related to the digestive tract, such as diarrhea, constipation, and vomiting. Other less common side effects reported have included hiccups, dry mouth, inflamed pancreas, and hypoglycemia.

What is the new warning on Ozempic? ›

The reason it's making headlines is because the FDA added a new warning to the Ozempic label. FDA said the medication will now include a warning about potential intestinal blockage. That legal warning was also added to the weight loss drug Wegovy, which is made by the same manufacturer as Ozempic.

How did Oprah lose weight? ›

How did Oprah lose weight? Winfrey has lost her latest weight using a weight-loss drug and with a healthy diet and exercising. She told People the weight-loss medication is just part of her regimen for maintaining a healthy weight. “I know everybody thought I was on it, but I worked so damn hard.

Is Oprah on Ozempic? ›

Oprah Winfrey shares the 'greatest' lesson she learned after filming Ozempic special. The talk show host focuses on the impact of anti-obesity medications in the new program after confirming she takes one herself.

Why won t my doctor prescribe Ozempic for weight loss? ›

Taking Ozempic for weight loss alone is an off-label use, meaning using it for a purpose it's not FDA-approved for. If your main goal is to lose weight, your provider may have you take Wegovy (semaglutide) instead. Wegovy is FDA-approved specifically for chronic weight management and weight loss.

What is the closest over the counter to Ozempic? ›

Are there any over-the-counter (OTC) Ozempic alternatives? Medications that work like Ozempic are only available with a prescription. But you may see OTC supplements, such as berberine, being promoted as natural Ozempic alternatives for weight loss.

How much weight can you lose in a month with Ozempic? ›

Research suggests that people can lose an average of 5 pounds monthly on Ozempic. The amount of weight you can lose in a month with Ozempic depends on your dose. Other factors affecting the amount of weight loss you can expect with Ozempic include your starting weight, diet, exercise, and other medications.

What is a natural alternative to Ozempic? ›

Natural alternatives to Ozempic for weight loss
  • Berberine. “Berberine improves the gut microbiota, which releases short-chain fatty acids, thereby increasing the release of GLP-1 from the intestines,” explains Dr. ...
  • Chromium. ...
  • Taurine. ...
  • Resveratrol. ...
  • Turmeric. ...
  • Green tea extract. ...
  • This probiotic combination. ...
  • Beta-glucan.
Aug 2, 2024

Why are people losing so much weight on Ozempic? ›

Ozempic works by mimicking a naturally occurring hormone. As those hormone levels rise, the molecules go to your brain, telling it you're full. It also slows digestion by increasing the time it takes for food to leave the body.

Why are doctors prescribing Ozempic to non diabetics? ›

Some doctors may prescribe Ozempic to help individuals without diabetes manage weight. But this use is considered “off-label” because it's not FDA approved for weight management. Wegovy is the FDA-approved weight loss version of Ozempic, explains Dr. Johnson, and contains the same active ingredient as Ozempic.

Why are celebrities using Ozempic? ›

The drug is approved to treat Type 2 diabetes and has weight loss as a prominent side effect, so it's often prescribed off-label for this reason. The active ingredient in Ozempic, semaglutide, is also approved to treat obesity under the name Wegovy.

Why do I feel so good on Ozempic? ›

The active ingredient in Ozempic is semaglutide, which works by inducing satiety. This feeling of being satisfied or “full”, suppresses appetite. This is why it works for weight loss. Semaglutide also helps the pancreas produce insulin, which is how it helps manage type 2 diabetes.

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